De Lara S, et al. - In this retrospective analysis, researchers used Cox regression analysis to assess FOXA1 (forkhead box protein A1) and Nestin expression as prognosticators in breast cancer metastases. They analyzed FOXA1, Nestin, and GATA3 expression using immunohistochemistry on 164 breast cancer metastases from various anatomical sites. In univariate Cox regression analysis, overall survival (OS) and metastasis-free survival, as well as, distant metastasis-free survival in estrogen receptor (ER)-positive patients, and overall survival in ER-negative patients were predicted by FOXA1 expression. FOXA1 was expressed mostly in ER-positive breast cancer metastases. Findings revealed a link between Nestin expression and triple-negative metastases; the most frequent metastatic site was the brain. FOXA1 and Nestin expression were clinically useful and should be included in routine immunohistochemical panels for breast cancer.