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The prognosis for glycemic status among children and youth with obesity 2 years after entering a weight management program

Pediatric Diabetes Apr 23, 2018

Al Khalifah R, et al. - Researchers attempted to elucidate the changes in glycemic status over 2 years, establish a predictive model for development of prediabetes among children with euglycemia and investigated the impact of change in body mass index (BMI) z-score on glycemic status in order to comprehend the longitudinal trajectory of dysglycemia in children with obesity. It was noted that the change in BMI z-score predicted dysglycemic status at 2 years. Among those euglycemic at baseline, the incidence of prediabetes was discovered to be 14 (8.2%) after 1 year, 20 (12.8%) at 2 years. Findings illustrated that the predictors of incident prediabetes were baseline BMI z-score; hazard ratio (HR): 1.72, 95th confidence interval (CI: 1.08, 2.74) and baseline HbA1c HR: 1.26, 95th CI (1.02-1.56) when controlling for age, family history of diabetes and sex. Hence, prediabetes depicted significant morbidity in children with obesity. Results indicated that family-based lifestyle interventions could delay prediabetes progression.
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