Verhelst J, et al. - The impact of GH replacement was investigated by the experts on the prevalence of MetS in adult-onset GH deficiency (AO-GHD). They also examined the effect of metabolic syndrome (MetS) on the incidence of cardiovascular events during GH replacement. Data displayed that the prevalence of MetS remained unchanged in AO-GHD during GH replacement. On the other hand, its components were differentially affected. Apart from GH replacement, consequent pharmacotherapy of all risk factors and endorsement of lifestyle intervention were pivotal together with early GHD diagnosis for the prevention of cardiovascular disease.