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The prevalence of 30 HPV genotypes detected by EUROArray HPV in cervical samples among unvaccinated women from Vojvodina province, Serbia

PLoS Neglected Tropical Diseases Apr 17, 2021

Kovacevic G, Milosevic V, Nikolic N, et al. - The pre-vaccination prevalence of HPV infection was examined according to age and cytological status among women from Vojvodina, Serbia. HPV genotyping assay was performed using the EUROArray HPV test in a total of 1,495 women in order to identify thirty genitally relevant HPV subtypes. The most prevalent genotypes were HPV 16, 31, 51, and 53 in this study. All cytological subgroups consistently showed presence of HPV 16. In 77.8.0% of (High grade Squamous Intraepithelial Lesions) or ASCH (Atypical Squamous Cells, cannot exclude HSIL) and 55.0% of NILM with abnormal colposcopy findings, they detected 12 HPV genotypes classified as carcinogenic to humans (Group 1). As per findings, Group 1 HPVs cause the majority of abnormal Pap test results among these women. They observed low frequency HPVs of group 2A/2B, especially HSIL/ASCH, supporting the necessity to consider individual genotypes of each type as an individual agent. HPV vaccine is expected to have a positive impact in lowering HPV-associated cervical lesions among these women.

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