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The preoperative neutrophil lymphocyte ratio and platelet lymphocyte ratio predicts disease-free survival in resectable esophageal squamous cell carcinoma

Cancer Management and Research Oct 04, 2021

Zheng Z, Yang C, Cai C, et al. - Disease-free survival in resectable esophageal squamous cell carcinoma (ESCC) was shown to be predicted by neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR).

  • According to recent studies, presence of systemic inflammation is related to poor survival for esophageal squamous cell carcinoma.

  • A total of 167 resectable ESCC patients were included.

  • Patients were classified into low NLR (< 2.20) or high NLR (≥ 2.20) group (AUC=62.5%, sensitivity 61.8%, specificity 60.9%), low PLR (< 110) or high PLR (≥ 110) group (AUC=59.6%, sensitivity 82.4%, specificity 35.3%).

  • High NLR and PLR were linked with a larger tumor diameter, while high NLR was also related to poor tumor classification.

  • A significant association of high NLR as well as PLR with poor disease-free survival was evident.

  • Multivariate studies showed NLR as a prognostic factor in resectable ESCC.

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