The preoperative neutrophil lymphocyte ratio and platelet lymphocyte ratio predicts disease-free survival in resectable esophageal squamous cell carcinoma
Cancer Management and Research Oct 04, 2021
Zheng Z, Yang C, Cai C, et al. - Disease-free survival in resectable esophageal squamous cell carcinoma (ESCC) was shown to be predicted by neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR).
According to recent studies, presence of systemic inflammation is related to poor survival for esophageal squamous cell carcinoma.
A total of 167 resectable ESCC patients were included.
Patients were classified into low NLR (< 2.20) or high NLR (≥ 2.20) group (AUC=62.5%, sensitivity 61.8%, specificity 60.9%), low PLR (< 110) or high PLR (≥ 110) group (AUC=59.6%, sensitivity 82.4%, specificity 35.3%).
High NLR and PLR were linked with a larger tumor diameter, while high NLR was also related to poor tumor classification.
A significant association of high NLR as well as PLR with poor disease-free survival was evident.
Multivariate studies showed NLR as a prognostic factor in resectable ESCC.
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