Prabhakaran S, Hocking A, Kim C, et al. - To assess the potential utility of GATA3 for prognostication as well as its clinical and pathological correlations in different subtypes of mesothelioma, researchers explored the immunohistochemical labelling as well as links for GATA3, BAP1 and Ki67 labelling in three major histological varieties of pleural malignant mesotheliomas. In 75/149 (50%) mesotheliomas, GATA3 was shown to be positive, with the highest incidence of labelling observed in the sarcomatoid subtype (73%), vs the biphasic (50%) and epithelioid (40%), mesotheliomas. No link of GATA3 labelling and BAP1 status or Ki67 index was evident. Overall, findings demonstrated the usefulness of GATA3 as a marker for sarcomatoid mesothelioma, including the desmoplastic subtype, in this study involving the largest cohort of mesotheliomas that has been labelled for GATA3 to date. Not uncommon was discordance in GATA3 and BAP1 labelling of epithelioid and sarcomatoid components in the biphasic subtype.