Kendler KS, et al. - In first marriages, researchers examined longitudinally the association of a first registration for alcohol use disorder (AUD) in one spouse with risk of registration in his or her partner. They also explored changes in the risk for AUD registration in individuals with multiple marriages as they transition from a spouse with AUD to one without or vice versa. In a married individual following a first AUD registration, the increase in risk for AUD registration in the spouse was large and rapid. When an individual was married in either order to serial partners with vs without alcohol use disorder, the risk for alcohol use disorder was substantially increased when the partner had an alcohol use disorder registration and decreased when the partner did not have an alcohol use disorder registration. The results thereby suggested that the presence of AUD in his or her spouse directly and causally affected a married individual’s risk for AUD.