Ye W, Liu Y, Liu WF, et al. - This research was sought to find the best number of administrations of oral tranexamic acid (TXA) for primary total knee and hip arthroplasty. Researchers carried out to search PubMed, Embase, and Cochrane Library databases for relevant studies published before March 20, 2020. A fixed-effects or random-effects model was applied to calculate the weighted mean variations and relative risks. This meta-analysis enrolled nine studies involving 1,678 patients (TXA 1363 (one administration, 201; two administrations, 496; three administrations, 215; four administrations, 336; five administrations, 115); placebo 315). This study's findings imply that oral TXA could significantly decrease the blood loss and the length of hospital stay but could not increase the incidence of deep vein thrombosis and intramuscular venous thrombosis for total joint replacement patients; additionally, the efficacy of oral TXA administration elevated as the number of administrations increased.