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The obesity-associated risk of cardiovascular disease and all-cause mortality is not lower in Inuit compared to Europeans: A cohort study of Greenlandic Inuit, Nunavik Inuit and Danes

Atherosclerosis Sep 12, 2017

Ronn PF, et al. - This research encompassed a comparison of the longitudinal correlations of anthropometric measures with cardiovascular (CVD) and all-cause mortality in Inuit and Europeans. Varied absolute incidences of CVD and all-cause mortality were displayed by Inuit and Europeans. However, the trends in the associations with the anthropometric measures varied just for all-cause mortality. The yielded data did not affirm previous findings of a lower obesity-associated cardiometabolic risk among Inuit.

Methods

  • Data was extracted from 3 population-based studies in Canada, Greenland and Denmark.
  • It recruited 10,033 adult participants (765 Nunavik Inuit, 2960 Greenlandic Inuit and 6308 Europeans).
  • Anthropometric measures collected at baseline comprised of BMI, WC, waist-to-hip-ratio (WHR), waist-to-height-ratio (WHtR) and a body shape index (ABSI).
  • Information on CVD and death was retrieved from national registers or medical files.
  • Poisson regression analyses measured the incidence rates for CVD and all-cause mortality.

Results

  • 642 CVD events and 594 deaths were reported during a median follow-up of 10.5 years.
  • There were slightly higher absolute incidence rates of CVD for a given anthropometric measure, in Nunavik Inuit compared with Greenlandic Inuit and the Europeans.
  • Nevertheless, there were no cohort interactions.
  • For all-cause mortality, a positive link was determined between all anthropometric measures in the Europeans, while only ABSI in the two Inuit populations.
  • On the other hand, BMI and WC exhibited an inverse link with mortality in the two Inuit populations.

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