Sharma A, et al. – An analysis was carried out to examine the combined treatment modality of the novel microtubule targeting agents (MTA) BAL101553 in combination with radiotherapy in paclitaxel and epothilone–resistant tumor models. As part of a combined treatment modality with ionizing radiation, BAL101553 was a promising alternative in taxane– and epothilone–refractory tumors. Targeting the tumor microenvironment, its potent antitumor effect was tumor cell–directed.