Asmar S, Lokhandwala A, Richards J, et al. - In this study, researchers examined how quetiapine influence outcomes in critically ill traumatic brain injury (TBI) patients. Querying the Multiparameter Intelligent Monitoring in Intensive Care database, they assessed data of all adult (age, ≥18 years) isolated TBI patients (extracranial Abbreviated Injury Scale, < 2) admitted to the intensive care unit for a period of > 48 hours. Performing propensity score matching, they obtained matched cohort of (quetiapine, 116 vs no-quetiapine, 232) patients. Outcomes suggest that decreased mortality and improved neurological outcomes may be achieved in critically ill TBI patients with providing quetiapine. It showed a dose-dependent effect to reduce intracranial pressure and increase cerebral perfusion pressure. Per findings, quetiapine seems to be a potential therapeutic option for critically ill TBI patients.