Alsaleem M, et al. - Using large, well-characterized cohorts, researchers evaluated the underlying mechanisms and molecular implications of E-cadherin [a tumor suppressor gene in invasive lobular breast cancer] loss in invasive ductal carcinoma. As per data, 27% of high-grade invasive ductal carcinoma exhibited reduced/loss of E-cadherin membranous expression. According to findings, E-cadherin loss in invasive ductal carcinoma is probably the result of genomic instability occurring during carcinogenesis. Potential novel regulators controlling the expression of E-cadherin in invasive ductal carcinoma should be investigated further.