Wang J, et al. - Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) and HPV-negative OPSCC were investigated for the genetic and epigenetic differences. From NCBI GEO datasets (GSE39366, GSE40774, and GSE55550) microarray data were included and analyzed. The analysis revealed three genes (VCAM1, UBD, and RPA2), two miRNAs (miR-107 and miR-142-3p), and four pathways (p53, PI3K-Akt, autophagy, and transcription dysregulation in cancer) that were recognized playing significant roles in differentiating HPV-positive OPSCC from HPV-negative OPSCC.