Beltran‐Valls MR, Santos R, Mota J, et al. - In this prospective cohort study, experts aspired to explore whether the connection between the cardiorespiratory fitness (CRF) at baseline and blood pressure (BP) at follow‐up is mediated by adiposity in adolescents. The sample consisted of 734 adolescents (349 girls) aged 12‐18 years from the LabMed Physical Activity Cohort Study. CRF was evaluated by the 20‐m shuttle run test. Adiposity mediated the link between CRF and BP in adolescents. Optimal CRF and adiposity levels are therefore important to maintain normal BP ranges throughout adolescence.