The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing
Molecular Carcinogenesis Oct 12, 2018
Gordon MA, et al. - In this study, the molecular mechanisms that facilitate ovarian cancer cell anchorage independent survival were recognized. For this investigation, researchers performed gene expression profiling on ovarian cancer cells grown in attached or forced suspension culture and confirmed by RT-qPCR. In ovarian cancer, the lncRNA Metastasis Associated Lung Adenocarcinoma transcript 1 (MALAT1) facilitates a pro-metastatic phenotype by promoting alternative RNA processing and differential expression of anti-apoptosis and epithelial to mesenchymal transition (EMT)-related genes. In addition, suppression of MALAT1 also resulted in reduced expression of RBFOX2, and alternative processing of the pro-apoptotic tumor suppressor gene KIF1B.
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