Yang X, et al. - Researchers assessed the relationship between an increased visit-to-visit variation of increased resting heart rate and SBP for all-cause mortality risk in the general population, based on an increase in 1 SD of HR or SBP among 46,751 residents of Tangshan city, China, via Cox proportional hazard model. Clinical characteristics assessed at the last examination (2010–2011) were adjusted. Follow-up of 4.97 ± 0.69 years revealed 1,667 deaths. The risk of all-cause mortality in general population, as well as in men and middle-age group, may be amplified by an elevated long-term SBP variability combined with an increased RHR variability or vice versa. In the subgroups of general population, men, and participants aged < 65 years, an increased risk of death was observed in relation to a rise in 1 SD of heart rate (4 bpm) among the participants in third and fourth quartile of SBP-SD, and an increased risk of death was observed in relation to 1-SD increase of SBP (7 mmHg) among the participants in the highest quartiles of RHR-SD.