Gandaglia G, Ploussard G, Valerio M, et al. - A total of 614 men who underwent MRI-targeted biopsy with concomitant systematic biopsy, with clinical stage ≤ T2 at the digital rectal examination, were included to generate novel models to prognosticate extracapsular extension (ECE), seminal vesicle invasion (SVI), or upgrading in individuals diagnosed with MRI-targeted and concomitant systematic biopsies. Models including mp-MRI, and MRI-targeted and concomitant systematic biopsy information attained the greatest AUC at internal validation for ECE, SVI, and upgrading and described the basis for three risk calculators that generate the greatest net advantage at DCA. To recognize individuals at a greater risk of adverse pathology, not only multiparametric-MRI and MRI-targeted sampling but also concomitant systematic biopsies gave important information. However omitting systematic prostate sampling at the time of MRI-targeted biopsy might be correlated with a decreased risk of identifying unimportant prostate cancer and lower patient discomfort, it decreases the ability to precisely prognosticate pathological characteristics.