İnan HC, et al. - In patients with laryngeal cancer, researchers examined the hyaluronic acid (HA) and hyaluronidase-1 (HYAL-1) levels. Between 2016 and 2017, 50 laryngeal squamous cell carcinoma patients and 50 volunteers who gave saliva samples investigated prospectively. In tumor tissue samples, HA levels were higher than in saliva samples, but there was no statistically significant difference between HA levels of saliva and tumor tissue. Compared with normal tissues of same patients, HYAL-1 expression in laryngeal squamous cell carcinomas is elevated. Future treatment of larynx cancer may be used to target this gene and HA catabolism products.