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The influence of prolonged temperature management on acute kidney injury after out-of-hospital cardiac arrest: A post hoc analysis of the TTH48 trial

Resuscitation Jun 03, 2020

Strand K, Søreide E, Kirkegaard H, et al. - Researchers undertook this sub-study among patients who participated in a randomised controlled trial (TTH48 trial) of targeted temperature management (TTM) at 33 °C for 24 vs 48 h following cardiac arrest, to determine the impact of prolonged TTM on acute kidney injury (AKI) as well as the incidence and factors related to the occurrence of AKI. Additionally, experts investigated how survival was influenced by AKI. Findings revealed no link between prolonged TTM at 33 °C and AKI risk during the first seven days in the ICU. Experts noted that AKI prevailed following cardiac arrest and TTM, and its development was evident in almost half of all ICU admitted patients and more often in the elderly, with a rising BMI and longer arrest duration. Time to death was independently predicted by AKI following cardiac arrest.

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