In this trial involving participants (n=26,730; aged 18–86 years) from the NutriNet-Santé study, researchers assessed the risk of incident depressive symptoms in relation to inflammatory potential of the diet, which was measured using the Alternate Dietary Inflammatory Index. They also investigated whether sex, age, body mass index, and lifestyle indicators had any modulating impact on the aforementioned link. The investigators estimated hazard ratios and 95% CIs using multivariable Cox proportional hazards models. Overall, they found a higher risk of depressive symptoms in relation to a proinflammatory diet, and this link was particularly pronounced among women, middle-age adults, and overweight or obese individuals. These findings, therefore, support prior scientific evidence that demonstrate the detrimental role of proinflammatory diet.