Yu PH, Hu CF, Liu JW, et al. - Researchers sought to evaluate the safety of using fluoroquinolones in the pediatric population in Taiwan. From the National Health Insurance Research Database, they selected patients aged 0~18 years old with fluoroquinolones prescriptions ≥ 5 consecutive days during the year 2000 to 2013 and selected 4-time case number as controls. They enrolled 167,105 patients; among these, 85 cases developed collagen-associated adverse effects (0.051%) in 6-month tracking, including 0.051% in the fluoroquinolones study cohort (17 in 33,421) and 0.051% (68 in 133,684) in the fluoroquinolones free comparison cohort. Findings suggest the fluoroquinolones group did not significantly differ from fluoroquinolones free group in terms of collagen-associated adverse effects. In view of these findings, it was proposed that for the pediatric population, fluoroquinolones maybe not so harmful in clinical practice as previous references reported.