Otagaki M, Fujii K, Matsumura K, et al. - Researchers assessed the fate of tissue protrusion (TP) following drug‐eluting stent (DES) deployment employing optical coherence tomography (OCT) in this prospective study. They examined TP for 42 lesions post-DES and three serial OCTs, including preprocedure, postprocedure, and 1‐month following the procedure were conducted. Five groups of TP were defined: (a) persistent, (b) progressive, (c) healed, (d) regressive, and (e) late‐acquired. They detected 100 TPs in 37 lesions (88%) immediately postprocedurally. Among those, persistent, progressive, healed were 53 (53%), 3 (3%), and 20 (20%), respectively, and 24 (24%) were regressed at 1‐month follow‐up. In five patients (13%), 7 TPs were noted only at 1‐month observation (late‐acquired). In this study, preprocedural OCT revealed calcified nodule as an underlying plaque morphology in lesions with late‐acquired TP. As per a serial OCT analysis, the occurrence of TP was identified not only immediately post-DES implantation but also 1‐month post-DES implantation.