Li Z, et al. - The incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection (EFC) were determined via retrospectively reviewing all patients with EFC diagnosed by transvaginal sonography (TVS) if they had undergone biopsy of the endometrium from January 2008 to January 2016 in a tertiary teaching hospital. Observations revealed a correlation of the risk of gynecologic malignancies in postmenopausal patients with EFC with genital symptoms, TVS findings and CA 125 levels. An extremely low risk of malignancy was noted in correlation to asymptomatic EFC.