Alqahtani S, et al. - In this systematic review and meta-analysis, researchers examined the incidence and outcomes of out-of-hospital cardiac arrests (OHCA) triggered by drug overdose (OD), an increasing public health problem in developed countries. Analyzing 12 articles (six from North America, four from Europe and two from Asia), they identified the pooled incidence of emergency medical services (EMS)-treated OHCA of 1.4 cases per 100,000 person-years. The pooled rate of survival to hospital discharge and survival with favorable neurological outcome was 9% and 6%, respectively. The pooled rate of return of spontaneous circulation of 25% was noted. Findings revealed a substantial variation in the incidence and survival outcomes of drug OD OHCA across regions emphasizing the necessity for effective strategies designed to reduce the incidence and improve survival outcomes.