Bjorn S, et al. - Researchers performed a prospective, randomized, double-blind, placebo-controlled trial to determine if a supplemental saphenous nerve block over and above a sciatic nerve block can be clinically significant with respect to providing analgesia after major ankle surgery. They presumed that a saphenous nerve block reduces the proportion of patients experiencing significant clinical pain after major ankle surgery. They focused on the proportion of patients reporting significant clinical pain as well as on maximal pain and analgesia of the cutaneous territory of the infrapatellar branch of the saphenous nerve following receipt of a popliteal sciatic nerve block and randomization to single-injection saphenous nerve block with 10 mL 0.5% bupivacaine with 1:200,000 epinephrine or 10 mL saline. Findings highlighted the importance of saphenous nerve as a contributor to postoperative pain following major ankle surgery, with significant clinical pain appearing within 30 minutes after surgery.