Ohashi T, Terasawa K, Aoki M, et al. - In this investigation involving 73 patients, researchers explored the connections between systemic inflammatory parameters and FDG-PET/CT parameters in advanced head and neck squamous cell carcinoma (HNSCC), and examined the links between FDG-PET/CT parameters and M2-macrophage polarization in HNSCC by evaluating the ratio of CD163, a M2-macrophage marker, to CD68, a pan-macrophage marker. The level of C-reactive protein (CRP), WBC count, and neutrophil count were associated with whole-body FDG-PET/CT parameters. The ratio CD163/CD68 correlated with both SUVmax and SUVmean. FDG-PET/CT has the potential to reflect chronic inflammation linked to cancer and immunosuppressive conditions in patients with cancer. FDG-PET/CT parameters seem useful in the evaluation of HNSCC immune status.