Ryu HJ, et al. - Researchers probed the recently identified receptor tyrosine kinases MET and tropomyosin-receptor kinase (Trk) as potential therapeutic targets in de novo salivary duct carcinoma. Findings suggested that in HER2-negative salivary duct carcinoma (SDC), high TrkA expression was significantly related to an inferior overall survival rate. Frequent events in SDC were the high expression of TrkA and c-MET and MET copy number gain/amplification. The tendency to be related to poor prognosis in HER2-negative SDC was revealed by high expression of TrkA. Findings suggested that possible therapeutic targets in SDC, especially in HER2-negative SDC could be TrkA and MET.