Cohen MS, et al. - Whether left ventricular (LV) size and function effect right ventricular (RV) function and clinical outcome following staged palliation for single-right ventricle anomalies was assessed in this Single Ventricle Reconstruction trial. For this analysis, echocardiography-derived measures of LV size and function were compared with measures of RV systolic and diastolic function, tricuspid regurgitation, and outcomes at baseline, early after Norwood palliation, before stage 2 palliation, and at 14 months of age. In infants with single-right ventricle anomalies, LV size varies by anatomic subtype. No difference was found in RV systolic function or transplantation-free survival based on LV measures, although indices of RV size and diastolic function were influenced by the presence of a left ventricle.