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The impact of the interval between the induction of chemotherapy and radiotherapy on the survival of patients with nasopharyngeal carcinoma

Cancer Management and Research Mar 31, 2019

Yang S, et al. - In this retrospective analysis of 239 local advanced nasopharyngeal carcinoma (NPC) patients who received concurrent chemoradiotherapy and induction chemotherapy (IC), researchers assessed outcomes relative to the interval between IC and initiating radiotherapy. Three groups of patients were defined taking into consideration the interval between IC and intensity-modulated radiation therapy (IMRT): Group A (≤7 vs >7 days), Group B (≤14 vs >14 days), and Group C (≤ 21 vs >21 days). Findings revealed no significant association of IC-IMRT interval with overall survival (OS), distant metastasis-free survival (DMFS), locoregional relapse-free survival (LRFS), or disease-free survival (DFS). OS, DMFS, LRFS, and DFS were significantly and independently predicted by tumor stage. Overall, in cases with an inability to receive treatment immediately due to chemotherapy complications such as bone marrow suppression, postponing radiotherapy for 1–3 weeks was feasible. However, initiating IMRT as soon as possible after IC was recommended.

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