Fucinari J, Elshaikh MA, Ruterbusch JJ, et al. - Utilizing Kaplan Meier methods and Cox proportional hazards modelling, researchers estimated overall survival, disease-specific survival, and progression-free survival among high-grade endometrial carcinoma cases and determined factors affecting survival for non-Hispanic white and non-Hispanic black women. BMI and race interact and modify the relationship with high-grade endometrial carcinoma survival. Other potentially modifiable factors like reducing comorbidities and expanding access to guideline-concordant treatment, may improve survival after diagnosis of high-grade endometrial carcinomas. A deeper understanding of the molecular drivers of these aggressive tumors could lead to targeted therapies that reduce the morbidity and mortality associated with them.