Chang JC, Davis AM, Klein‐Gitelman MS, et al. - Researchers intended to determine if there is a correlation between psychiatric disorders and hydroxychloroquine adherence and determined if psychiatric treatment modifies this connection. Incident hydroxychloroquine users were identified among SLE youth (aged 10 to 24 years) using de‐identified U.S. commercial insurance claims in Optum Clinformatics Data Mart (2000‐2016). Among 873 individuals, 20% had a psychiatric diagnosis, most commonly depression. Psychotropic medication use was correlated with a 0.15 increase in medication possession ratios (MPR) compared with no psychotropic medication among youth with any psychiatric diagnosis. In addition, psychotherapy was related to a higher MPR compared with no psychotherapy among youth with depression or anxiety. The effect of psychiatric disorders on medication adherence varied by whether youth had received psychiatric treatment. Improving the identification and treatment of psychiatric conditions can increase adherence in SLE youth.