Grabel ZJ, et al. - Experts ascertained the effect of prophylactic intraoperative vancomycin powder on microbial profile, antibiotic regimen, length of stay, and reoperation rate in spine surgical site infection (SSI). Findings suggested an association of vancomycin powder with a higher prevalence of gram-negative and polymicrobial organisms in patients that ultimately developed post-operative SSI. Nonetheless, the need for multiple reoperations, antibiotic regimen, or length of stay for these patients was not adversely affected by this association.