Ashida R, et al. - In a double-blinded randomized ­controlled trial, researchers determined if preoperative enteral diets ­enriched in eicosapentaenoic acid (EPA) supplements influence the incidence of hypercytokinemia after pancreatoduodenectomy (PD). Patients with resectable periampullary cancer were randomized into either the control group receiving isocaloric isonitrogenous standard nutrition (600 kcal/day) without EPA for 7 days before surgery or the treatment group receiving oral supplementation (600 kcal/day) containing EPA for 7 days before surgery. Outcomes revealed no marked impact of preoperative immunonutrition on the rates of postoperative hypercytokinemia or infectious complications after PD.