Sharma M, et al. - Through a retrospective review of 115 radical cystectomy cases where perivesical lymph nodes (PVLNs) had been histologically evaluated, researchers comparatively examined the outcome of groups of patients with or without positive PVLN and/or non-PVLN who underwent radical cystectomy and pelvic lymphadenectomy for bladder cancer. In bladder cancer patients with isolated PVLN metastasis (vs pN0 disease especially for cancer-specific survival), PVLN metastasis with or without non-PVLN metastasis (vs pN0 disease), and concurrent PVLN and non-PVLN metastases (vs PVLN-negative/non-PVLN-positive disease especially for overall survival), the worse prognosis was recognized. Thus, in radical cystectomy specimens, the significance of a thorough histopathological evaluation of PVLNs was suggestive.