Kelsey MM, Pyle L, Hilkin A, et al. - Youth with normal weight (n = 47; 22 females, 25 males) vs those with obesity (n = 37; 23 females, 14 males) were compared during pubertal progression regarding longitudinal changes in insulin sensitivity (Si) and secretion. Significantly lower Si and higher acute insulin response to glucose were identified among youth with obesity at each time point, however, the groups were similar regarding disposition index was similar between. This findings suggest significant influences of obesity on Si during puberty, even at the earliest stages. However, adequate β-cell compensation occurs in obese youth, in general, for the significantly decreased Si of puberty.