Chiappetta S, et al. - Researchers compared the different bariatric procedures sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and One-anastomosis gastric bypass (OAGB), pertaining to their effects on inflammation markers. They found C-reactive protein (CRP) but not leukocyte count diminished after all three bariatric procedures but without any significance between the three groups. For improvement in chronic inflammation, surgically induced weight loss and not anatomical changes could play an important role.

Methods

• Participants in the study were patients who underwent SG, RYGB, or OAGB as a primary treatment for severe obesity.
• The information gathered preoperatively (T0) and 1, 3, and 6 (T6) months after surgery included gender, weight, comorbidities and toxic habits at baseline, body mass index (BMI), waist circumference, total body weight loss in % (TBWL), leukocyte count in × 10³/μl, CRP in mg/l, HbA1c in %, aspartate transaminase in U/l, alanine transaminase in U/l, gamma-glutamyltransferase in U/l, bilirubin in mg/dl, cholesterol in mg/dl, and triglycerides in mg/dl.

Results

• Four hundred sixty-eight patients were incorporated in this analysis.
• The study results showed that drop-out rate was 25.8% at T6.
• It was noted that preoperatively the mean value of leukocytes and CRP was 7.4 × 10³/μl ± 2 and 10.5 mg/l ± 8.1.
• Findings revealed that mean value of leukocytes and CRP was 7.1 × 10³/μl ± 1.9 (p=0.075) and 7.2 mg/l ± 9.5 (p < 0.001) at T6.
• It was observed that TBWL % at T6 was 24.2 ± 7.6 in the SG, 25.8 ± 5.9 in the RYGB and 25.5 ± 4.6 in the OAGB group.
• No significant difference was noticed between the groups, comparing SG, RYGB, and OAGB in relation to leukocyte count and CRP.