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The impact of modifiable risk factors on the long-term outcomes of non-alcoholic fatty liver disease

Alimentary Pharmacology and Therapeutics Dec 07, 2019

Paik JM, et al. - Given the development of 7 cardiovascular (CV) health metrics (poor, intermediate and ideal health) by the American Heart Association to improve CV health, researchers sought to determine population-attributable fractions of CV health metrics to all-cause and CV mortality among patients with non-alcoholic fatty liver disease (NAFLD). From the National Health and Nutrition Examination Survey (NHANES 1988-1994), they included 4,040 adults with NAFLD and 7,515 without. Following median follow-up of 19.2 years, the death of 1,136 NAFLD individuals (327 CV deaths) and 1,600 non-NAFLD individuals (447 CV deaths) was reported. Lower risk for all-cause and CV mortality was noted with the attainment of the increased number of ideal health metrics. They estimated that 66% of all-cause deaths and 83% of CV deaths were preventable in case all NAFLD individuals achieved 7 ideal health metrics. Lack of glycaemic control and hypertension were the largest mortality contributors among NAFLD individuals.
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