Moustafa M, Fasolo E, Bassi D, et al. - Researchers performed this work examining how liver resection (LR) influences the prognosis of locally advanced Intrahepatic Cholangiocarcinoma (IC) in comparison to alternative palliative chemotherapy (CTx). Employing Surveillance, Epidemiology, and End Results database, locally advanced IC patients were identified. Locally advanced IC was defined as follows on the bases of the American Joint Committee on Cancer (AJCC) Staging System: Stage III and IVa - 7th edition (7th-ed) or stage III - 8th edition (8th-ed). Sub-classification of the study population was done as follows: LR group (n = 154) and a propensity score matched CTx group (n = 154). The analysis revealed a correlation of hepatic resection with a favorable impact on prognosis over chemotherapy for IC stage III and IVa of the 7th edition and for stage IIIb of 8th edition of AJCC staging system. LR patients > 65 years and with multifocal lesions exhibited worse outcomes.