The impact of hypothermia on outcomes in massively transfused patients
The Journal of Trauma and Acute Care Surgery Mar 09, 2019
Lester ELW, et al. - Given the association of hypothermia with poor outcomes after injury, researchers examined how hypothermia during contemporary large volume resuscitation influence blood product consumption. In addition, they sought the predictive value of hypothermia for mortality. In the Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial, they randomized patients who were predicted to receive massive transfusion at 12 level 1 trauma centers and grouped them into those who were hypothermic (<36°C) or normothermic (36-38.5°C) within the first 6 hours of Emergency Department arrival. Among the 680 patients, the temperature was measured in 590 during the first 6 hours in hospital, and hypothermia was reported in 399. Findings suggest increased blood product consumption and mortality in correlation with hypothermia. Findings thereby support the maintenance of normothermia in trauma patients.
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