Lee A, Haddad D, Rybin D, et al. - Researchers investigated how perioperative hemoglobin A1C (HbA1c) level affects perioperative outcomes following lower extremity bypass (LEB). Using Vascular Quality Initiative (VQI) database (2007-2018), they identified a cohort of 8,171 infrainguinal LEBs with chronic limb-threatening ischemia (CLTI). Of these patients, 860 (7.2%) had HbA1c < 5.7%, 2,563 (21.6%) 5.7%-6.5%, and 8,447 (71.2%) > 6.5% (2,792 had HbA1c 6.6%-7.4%, 2,357 7.5%-8.5%, and 3,298 > 8.5%). In multivariable analysis, no significant link was noted between HbA1c and wound infection in the CLTI cohort. However, there was a significant link between reduced HbA1c and mortality. Outcomes here suggest no significant link of raised HbA1c level with perioperative complications.