The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study
Osteoporosis International Nov 19, 2017
Modi A, et al. - The relationship between gastrointestinal (GI) events and self-reported levels of medication adherence and persistence in postmenopausal women was investigated in this multinational, prospective, observational study. The researchers found an association between the occurrence of GI events with a lower likelihood of patient adherence to and persistence with osteoporosis (OP) medication.
Methods
- The Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study was a multinational, prospective, observational study.
- This study investigated the impact of GI events on OP management in postmenopausal women.
- The researchers collected information regarding GI events at the time of enrollment and at months 3, 6, and 12 of follow-up.
- GI events and medication persistence were reported by patients.
- Patients completed the 12-item Adherence Evaluation of Osteoporosis treatment (ADEOS) questionnaire.
- They examined the association between GI events at various time points and persistence and adherence at month 12 through multivariate logistic and general linear models.
Results
- A total of 2,943 women were enrolled; 22.8% were classified as new users of OP therapy and the remainder were considered experienced users.
- In this study, 68.1% reported GI events at baseline across all patients.
- Over 80% of subjects who completed follow-up reported at least 1 GI problem, by month 12.
- At baseline, the majority of patients (86.7%) were treated only with bisphosphonates.
- Findings revealed that 73.9% of patients remained on therapy at month 12.
- Logistic regression demonstrated that after adjusting for other factors, those with GI problems by month 6 were significantly less likely to persist with treatment.
- Among patients who experienced a GI event between baseline and month 6, the odds of a month 12 ADEOS score ≥ 20 (considered predictive of adherence) were significantly lower.
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