Ajmera V, Liu A, Bettencourt R, et al. - This study was carried out to assess the impact of PNPLA3, TM6SF2, MBOAT7, GCKR and HSD17B13 genotype on liver fibrosis assessed by magnetic resonance elastography (MRE), a reproducible, accurate, continuous biomarker of liver fibrosis. Researchers designed a cross‐sectional analysis derived from a well‐characterized cohort at risk for non‐alcoholic fatty liver disease (NAFLD) who had undergone genotyping and MRE assessment. Using MRE, Liver stiffness (LS) was calculated, and advanced fibrosis was defined as liver stiffness ≥ 3.63 kilopascals. The relationship between genotype and MRE was assessed by using univariable and multivariable linear and logistic regression analysis. They included a total of 264 patients (63% women) with a mean age of 53 (±17) years, and 31% Hispanic ethnicity with genotyping and MRE. The results demonstrate that understanding of PNPLA3 and HSD17B13 genotypes may assist in the non‐invasive risk stratification of NAFLD with closer monitoring recommended for those with high genetic risk.