The impact of first untreated subclinical minimal acute rejection on risk for chronic lung allograft dysfunction or death after lung transplantation
American Journal of Transplantation Aug 17, 2019
Levy L, Huszti E, Tikkanen J, et al. - Researchers hypothesized that an untreated first spirometrically-stable A1 rejection (StA1R) does not raise the risk of chronic lung allograft dysfunction (CLAD) or death in comparison with episodes of spirometrically-stable no acute cellular rejection (ACR) (StNAR). No important variation in risk of CLAD or death in patients with a first StA1R vs StNAR was exhibited by the analyses. Thus, an untreated first A1 ACR in the first-year posttransplant was not significantly correlated with an elevated risk for CLAD or death in clinically stable patients. In LT recipients, watchful-waiting approach may be an acceptable way for stable A1 episodes.
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