Zhu Y, Shudo Y, Lingala B, et al. - Researchers focused on the influence of donor gender on results of heart transplantation in the United States. A total of 63,775 adult patients who had heart transplantation were matched to 27,509 male and 11,474 female donors in the United States, from 1987 to March 2019. Propensity matching was applied which resulted in 15,506 and 1,094 patients based on donor gender and menopause status, respectively. More chance of experiencing acute rejection episodes necessitating anti-rejection medical treatment as well as of requiring post-transplant dialysis was noted in recipients who received female donor allografts vs those who received male donor allografts. Findings generated by analyzing the United Network for Organ Sharing database revealed that median survival was similar using female vs male donor hearts in adult heart transplantation, regardless of donor menopause status. Far less frequent use of female donor allografts was documented, therefore these data offer an opportunity to maximize usage via better utilization of suitable female donor organs.