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The impact of diagnostic wait time on the survival of patients with diffuse large B-cell lymphoma: Effect modification by the International Prognostic Index

British Journal of Haematology Jul 05, 2019

Lee S, et al. - Researchers looked at the link between diagnostic wait time (DWT), the interval from the initial hospital visit to diagnosis, and survival in patients with diffuse large B-cell lymphoma (DLBCL) (n=193) in this single-centre, retrospective study. According to the International Prognostic Index (IPI), a subgroup analysis was also performed. In the whole DLBCL population, no link was found between DWT and survival. Between IPI < 3 and ≥ 3, a differential influence of DWT on survival was evident; the prognosis in patients with IPI ≥ 3 was steadily exacerbated by DWT prolongation, whereas a high mortality rate despite rather an early diagnosis was seen in a patient population with IPI < 3. Survival in all DLBCL patients was offset by the opposite trend in the impact of DWT on survival between patients with IPI < 3 and ≥ 3. Overall, the whole DLBCL population showed no observable influence of DWT on outcomes, but the worsening of the prognosis was reported in relation to longer DWT, especially in patients with IPI ≥ 3.
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