Qin Z, Xiang C, Li H, et al. - Including patients (n= 125) undergoing laparoscopic gynecological surgery, researchers undertook this prospective and randomized double-blind study to determine the impact of the addition of dexmedetomidine (a highly selective alpha-2 adrenergic agonist) into ropivacaine for ultrasound-guided transversus abdominis plane block on stress response during laparoscopic surgery. They also looked for the optimal dose of dexmedetomidine in it. For the four-quadrant transversus abdominis plane block (n = 25), they administered general anesthesia to patients with or without a total of 60 ml of 0.2% ropivacaine in combination with low (0.25 μg/kg), medium (0.50 μg/kg) or high dose (1.0 μg/kg) of dexmedetomidine. The optimal dose of dexmedetomidine for addition into ropivacaine for ultrasound-guided transversus abdominis plane block was identified to be 0.5 μg/kg, which when administered resulted in the inhibition of stress response and had a limited influence on blood pressure and heart rate in patients undergoing laparoscopy gynecological surgery.