Mills JC, et al. - From the Women's Interagency HIV Study at 9 sites across the US, researchers examined a cohort of 1,491 women living with HIV (WLWH) in order to assess insight into the association between accumulated depression and HIV disease management. In this longitudinal observational cohort study (2013–2017), WLWH were followed for a maximum of 9 semiannual visits. With increasing percent of days depressed (PDD), monotonic increase in the risk of missing an HIV care appointment [risk ratio (RR) = 1.16, 95% confidence interval = 0.93 to 1.45; risk difference (RD) = 0.01, −0.01 to 0.03], being < 95% ART adherent (RR = 1.27, 1.06–1.52; RD = 0.04, −0.01 to 0.07), and virological failure (RR = 1.09, 1.01–1.18; RD = 0.01, −0.01 to 0.03) were observed (comparing those with 25 to those with 0 PDD). Being < 95% ART adherent fully (%100) mediated the total effect of PDD on virological failure.