Stawicki SP, Wolfe S, Brisendine C, et al. - Researchers here examined if the use of the advanced air purification technology would reduce health care durations of stay, result in fewer nonhome discharges, and reduce hospital charges. Three resultant air purification “zones” were established following the installation of advanced air purification technology: zone C, a control floor with high efficiency particulate air filtration; zone B, a mixed high efficiency particulate air and advanced air purification technology floor; and zone A, a comprehensive advanced air purification technology remediation. They included 1,002 nonbariatric surgical patients admitted across the 3 zones between December 2017 and December 2018; mean age was 55.8 years (53.7% female), average case mix index was 1.98, and mortality was 1.7%. Observations revealed statistically significant improvements in durations of stay, discharge to home, and costs among patients in the advanced air purification technology zones after adjusting for case mix index. Further, they observed a trend toward fewer hospital-acquired infections in advanced air purification technology zones. These findings are suggestive of the effect of environmental factors on key clinical and economic outcomes, supporting further research in this important and largely unexplored area.