Wang X, Chen G, Zhang Y, et al. - In this retrospective study, researchers examined the impact of circumferential tumor location on neoadjuvant chemoradiotherapy (CRT) response and its prognostic value for locally advanced rectal cancer (LARC) patients after CRT and surgery. This investigation was conducted on patients (n = 486) with LARC who received neoadjuvant CRT and surgical treatment. The anterior tumors showed the highest pCR rate of 26.7%, which for lateral and posterior tumors was slightly higher than the 20.0% and 12.3%, respectively. This study is the first to show that the anterior LARC after neoadjuvant CRT exhibited the highest pCR rate. Patients with anterior rectal cancer who undergo neoadjuvant CRT do not have different prognoses than those with nonanterior cancers.