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The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: The EPIPAGE-2 cohort study

BJOG: An International Journal of Obstetrics and Gynaecology Feb 19, 2020

Tosello B, et al. - Researchers conducted a prospective nation-wide population-based EPIPAGE-2 cohort study including a total of 1,700 twin neonates born between 24-34 weeks of gestation (850 twin pregnancies) in order to ascertain how the chorionicity of pregnancy influences the short and mid-term outcomes of preterm twins. Of these, 1,220 (71.8%) were from Dichorionic (DC) pregnancies and 480 from monochorionic (MC) pregnancies. MC vs DC pregnancies had three times more medical terminations (1.67% vs 0.51%) while MC vs DC pregnancies were observed correlated with three times more stillbirths (10.09% vs 3.78%). In DC pregnancies, 86.6% resulted in twins that were both alive at birth vs 80.0% among MC pregnancies. Findings thereby establish a greater risk of adverse outcomes in MC pregnancies. However, preterm twins admitted to neonatal intensive care units had similar outcomes; these outcomes showed no correlation with the chorionicity of pregnancy.
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